Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT.

LIGHT (TNFSF14) is a member of the TNF superfamily and is known to substitute for RANKL to induce osteoclast differentiation. LIGHT binds HVEM and LTβR, but it is not known whether these receptors play a role in osteoclast formation or whether LIGHT acts via RANKL signalling pathways. We found that...

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Hlavní autoři: Hemingway, F, Kashima, T, Knowles, H, Athanasou, N
Médium: Journal article
Jazyk:English
Vydáno: 2013

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