Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Show other versions (1)

Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fl...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Simone, D, Penkava, F, Ridley, A, Sansom, S, Al-Mossawi, M, Bowness, P
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Springer Nature 2021

Antzeko izenburuak

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates
nork: Simone, D, et al.
Argitaratua: (2021)

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis
nork: Al-Mossawi, M, et al.
Argitaratua: (2013)

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis.
nork: Al-Mossawi, M, et al.
Argitaratua: (2013)

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
nork: Penkava, F, et al.
Argitaratua: (2020)

Natural killer cell and synovial fibroblast cross talk - A role in the pathogenesis of spondyloarthritis
nork: Chan, A, et al.
Argitaratua: (2006)

HLA-B27 and KIR3DL2 Interactions Promote The Differentiation and Survival Of Proinflammatory T Cells In Spondyloarthritis
nork: Ridley, A, et al.
Argitaratua: (2013)

Novel therapeutic targets in axial spondyloarthritis
nork: Worth, C, et al.
Argitaratua: (2018)

BROMODOMAIN INHIBITORS REDUCE TH17-TYPE RESPONSES IN SPONDYLOARTHRITIS IN VITRO
nork: Hammitzsch, A, et al.
Argitaratua: (2014)

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
nork: Frank Penkava, et al.
Argitaratua: (2020-09-01)

Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid
nork: Yager, N, et al.
Argitaratua: (2021)

A proinflammatory response is mediated by synovial fibroblast and natural killer cell interaction in rheumatoid arthritis and spondyloarthritis
nork: Chan, A, et al.
Argitaratua: (2008)

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis
nork: Ekaterina A. Komech, et al.
Argitaratua: (2022-10-01)

The Clonal Fate of Live Cells
nork: Wei Wang, et al.
Argitaratua: (2017-06-01)

T cell phenotype and function in Spondyloarthritis
nork: Ridley, AL
Argitaratua: (2013)

Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid
nork: Yager, N, et al.
Argitaratua: (2021)

Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in spondyloarthritis
nork: Ridley, A, et al.
Argitaratua: (2016)

Elevated type-17 cytokines are present in Axial Spondyloarthritis stool
nork: Brough, I, et al.
Argitaratua: (2024)

Pathogenic immune responses in Spondyloarthritis
nork: Al-Mossawi, M
Argitaratua: (2016)

PHENOTYPIC CHARACTERIZATION OF NATURAL KILLER CELLS AND RECEPTORS IN SPONDYLOARTHRITIS
nork: Chan, A, et al.
Argitaratua: (2004)

Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis
nork: Alexandra Argyriou, et al.
Argitaratua: (2022-07-01)

IL-17 producing mast cells contribute to synovial inflammation in non-psoriatic and psoriatic spondyloarthritis
nork: Noordenbos Troy, et al.
Argitaratua: (2011-11-01)

Supplementary figures for "Inhibiting HLA-B27 homdimer-driven immune cell inflammation in Spondyloarthritis"
nork: Bowness, P
Argitaratua: (2012)

Barcode clonal tracking of tissue-resident immune cells in rhesus macaque highlights distinct clonal distribution pattern of tissue NK cells
nork: Chuanfeng Wu, et al.
Argitaratua: (2022-11-01)

Distinct gene regulatory dynamics drive skeletogenic cell fate convergence during vertebrate embryogenesis
nork: Menghan Wang, et al.
Argitaratua: (2025-03-01)

The KIRs of HLA-B27: the role of HLA-B27 KIR interactions in infection and spondyloarthritis
nork: Wong-Baeza, I, et al.
Argitaratua: (2011)

T-cell stimuli independently sum to regulate an inherited clonal division fate
nork: J. M. Marchingo, et al.
Argitaratua: (2016-11-01)

Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis
nork: Paley, MA, et al.
Argitaratua: (2024)

Unique trancriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
nork: Al-Mossawi, M, et al.
Argitaratua: (2017)

Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain
nork: Scholl Catharina, et al.
Argitaratua: (2012-07-01)

T cell-mediated immune regulation in spondyloarthritis
nork: Simone, D
Argitaratua: (2020)

miR-10b-5p is a novel Th17 regulator present in Th17 cells from Ankylosing Spondylitis
nork: Chen, L, et al.
Argitaratua: (2017)

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
nork: M. H. Al-Mossawi, et al.
Argitaratua: (2017-11-01)

Clonal analysis of the Arabidopsis root confirms that position, not lineage, determines cell fate.
nork: Kidner, C, et al.
Argitaratua: (2000)

Anti-tumour necrosis factor therapy in seronegative spondyloarthritis.
nork: Catherine, S, et al.
Argitaratua: (2005)

Distinct Injury Responsive Regulatory T Cells Identified by Multi-Dimensional Phenotyping
nork: Fei Guo, et al.
Argitaratua: (2022-05-01)

Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo
nork: Alison G Cole, et al.
Argitaratua: (2024-01-01)

Comparative study of the synovial levels of RANKL and OPG in rheumatoid arthritis, spondyloarthritis and osteoarthritis
nork: Thaíse Oliveira Quaresma, et al.
Argitaratua: (2023-03-01)

Immune effector cells in SpA: What are the pathways?
nork: Bowness, P, et al.
Argitaratua: (2018)

The role of HLA-B27 in spondyloarthritis.
nork: Allen, R, et al.
Argitaratua: (1999)

Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells
nork: Mary Elise L. Severino, et al.
Argitaratua: (2024-12-01)