Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases
Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD3-finger of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were o...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2018
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