Design and analysis of genome-wide association studies

Design and analysis of genome-wide association studies

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and...

Deskribapen osoa

Xehetasun bibliografikoak
Egile nagusia:	Barrett, J
Beste egile batzuk:	Donnelly, P
Formatua:	Thesis
Hizkuntza:	English
Argitaratua:	2008
Gaiak:	Mathematical genetics and bioinformatics (statistics) Genetics (life sciences)

Antzeko izenburuak

Gene x gene interactions in genome wide association studies
nork: Bhattacharya, K
Argitaratua: (2014)

Bayesian and frequentist methods and analyses of genome-wide association studies
nork: Vukcevic, D
Argitaratua: (2009)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
nork: Repapi, E
Argitaratua: (2013)

Extensions of the case-control design in genome-wide association studies
nork: Loizides, C
Argitaratua: (2012)

Quantifying the underestimation of relative risks from genome-wide association studies
nork: Spencer, C, et al.
Argitaratua: (2011)

Large-scale genetic analysis of quantitative traits
nork: Randall, J, et al.
Argitaratua: (2012)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
nork: Meader, S
Argitaratua: (2010)

The estimation of recombination rates from population genetic data
nork: Auton, A
Argitaratua: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
nork: Pfeifer, S
Argitaratua: (2012)

Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq
nork: Hosseini, M
Argitaratua: (2013)

Imputation aided analysis of the association between autoimmune diseases and the MHC
nork: Moutsianas, L
Argitaratua: (2011)

A method for the identification of biological pathways
nork: Honti, F
Argitaratua: (2014)

Genome annotation and selectional analysis of viral evolution
nork: de Groot, S
Argitaratua: (2008)

Using phylogeny to improve genome-wide distant homology recognition
nork: Abeln, S, et al.
Argitaratua: (2007)

Statistical methods for the analysis of genetic association studies
nork: Su, Z
Argitaratua: (2008)

On genetic variants underlying common disease
nork: Hechter, E
Argitaratua: (2011)

Bayesian methods for multivariate phenotype analysis in genome-wide association studies
nork: Iotchkova, V
Argitaratua: (2013)

Bayesian methods for fine mapping in genetic association studies
nork: Frangou, E
Argitaratua: (2013)

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing
nork: Venn, O
Argitaratua: (2013)

Multilocus sequence analysis of the pathogen Neisseria meningitidis
nork: Wilson, D
Argitaratua: (2005)

Statistical HLA type imputation from large and heterogeneous datasets
nork: Dilthey, A
Argitaratua: (2012)

Comparative analysis of derived mutations across human populations.
nork: Feder, A, et al.
Argitaratua: (2013)

Exploring the fold space preferences of ancient and newborn protein superfamilies
nork: Edwards, H, et al.
Argitaratua: (2014)

Medical relevance and functional consequences of protein truncating variants
nork: Rivas Cruz, M
Argitaratua: (2015)

Statistical methods for mapping complex traits
nork: Allchin, L
Argitaratua: (2014)

LD-based SNP and genotype calling from next-generation sequencing reads.
nork: Menelaou, A
Argitaratua: (2012)

Probabilistic models of RNA secondary structure
nork: Anderson, JWJ
Argitaratua: (2013)

Statistical methods for genotype microarray data on large cohorts of individuals
nork: O'Connell, JM
Argitaratua: (2014)

The detection, structure and uses of extended haplotype identity in population genetic data
nork: Xifara, DK
Argitaratua: (2014)

Multiple sequence analysis in the presence of alignment uncertainty
nork: Herman, J, et al.
Argitaratua: (2014)

NucleoFinder: a statistical approach for the detection of nucleosome positions
nork: Becker, J, et al.
Argitaratua: (2013)

Bayesian methods for estimating human ancestry using whole genome SNP data
nork: Churchhouse, C
Argitaratua: (2012)

Protein fold evolution on completed genomes: distinguishing between young and old folds
nork: Abeln, S, et al.
Argitaratua: (2007)

Fold recognition and alignment in the ‘twilight zone’
nork: Hill, J, et al.
Argitaratua: (2013)

GAT: a simulation framework for testing the association of genomic intervals
nork: Heger, A, et al.
Argitaratua: (2013)

Whole-genome analysis of the transcriptional network underlying male sexual behaviour in Drosophila melanogaster
nork: Ashley, E, et al.
Argitaratua: (2012)

Accessing complex genomic variation in Plasmodium falciparum natural infections
nork: Wendler, J
Argitaratua: (2015)

Increasing statistical power and generalizability in genomics microarray research
nork: Ramasamy, A
Argitaratua: (2009)

The evolutionary dynamics of neutral networks: lessons from RNA
nork: Rendel, M
Argitaratua: (2008)

Statistical models for single-cell data
nork: Pierson, E
Argitaratua: (2015)