Design and analysis of genome-wide association studies

Design and analysis of genome-wide association studies

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and...

Полное описание

Библиографические подробности
Главный автор:	Barrett, J
Другие авторы:	Donnelly, P
Формат:	Диссертация
Язык:	English
Опубликовано:	2008
Предметы:	Mathematical genetics and bioinformatics (statistics) Genetics (life sciences)

Схожие документы

Gene x gene interactions in genome wide association studies
по: Bhattacharya, K
Опубликовано: (2014)

Bayesian and frequentist methods and analyses of genome-wide association studies
по: Vukcevic, D
Опубликовано: (2009)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
по: Repapi, E
Опубликовано: (2013)

Extensions of the case-control design in genome-wide association studies
по: Loizides, C
Опубликовано: (2012)

Quantifying the underestimation of relative risks from genome-wide association studies
по: Spencer, C, и др.
Опубликовано: (2011)

Large-scale genetic analysis of quantitative traits
по: Randall, J, и др.
Опубликовано: (2012)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
по: Meader, S
Опубликовано: (2010)

The estimation of recombination rates from population genetic data
по: Auton, A
Опубликовано: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
по: Pfeifer, S
Опубликовано: (2012)

Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq
по: Hosseini, M
Опубликовано: (2013)

Imputation aided analysis of the association between autoimmune diseases and the MHC
по: Moutsianas, L
Опубликовано: (2011)

A method for the identification of biological pathways
по: Honti, F
Опубликовано: (2014)

Genome annotation and selectional analysis of viral evolution
по: de Groot, S
Опубликовано: (2008)

Using phylogeny to improve genome-wide distant homology recognition
по: Abeln, S, и др.
Опубликовано: (2007)

Statistical methods for the analysis of genetic association studies
по: Su, Z
Опубликовано: (2008)

On genetic variants underlying common disease
по: Hechter, E
Опубликовано: (2011)

Bayesian methods for multivariate phenotype analysis in genome-wide association studies
по: Iotchkova, V
Опубликовано: (2013)

Bayesian methods for fine mapping in genetic association studies
по: Frangou, E
Опубликовано: (2013)

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing
по: Venn, O
Опубликовано: (2013)

Multilocus sequence analysis of the pathogen Neisseria meningitidis
по: Wilson, D
Опубликовано: (2005)

Statistical HLA type imputation from large and heterogeneous datasets
по: Dilthey, A
Опубликовано: (2012)

Comparative analysis of derived mutations across human populations.
по: Feder, A, и др.
Опубликовано: (2013)

Exploring the fold space preferences of ancient and newborn protein superfamilies
по: Edwards, H, и др.
Опубликовано: (2014)

Medical relevance and functional consequences of protein truncating variants
по: Rivas Cruz, M
Опубликовано: (2015)

Statistical methods for mapping complex traits
по: Allchin, L
Опубликовано: (2014)

LD-based SNP and genotype calling from next-generation sequencing reads.
по: Menelaou, A
Опубликовано: (2012)

Probabilistic models of RNA secondary structure
по: Anderson, JWJ
Опубликовано: (2013)

Statistical methods for genotype microarray data on large cohorts of individuals
по: O'Connell, JM
Опубликовано: (2014)

The detection, structure and uses of extended haplotype identity in population genetic data
по: Xifara, DK
Опубликовано: (2014)

Multiple sequence analysis in the presence of alignment uncertainty
по: Herman, J, и др.
Опубликовано: (2014)

NucleoFinder: a statistical approach for the detection of nucleosome positions
по: Becker, J, и др.
Опубликовано: (2013)

Bayesian methods for estimating human ancestry using whole genome SNP data
по: Churchhouse, C
Опубликовано: (2012)

Protein fold evolution on completed genomes: distinguishing between young and old folds
по: Abeln, S, и др.
Опубликовано: (2007)

Fold recognition and alignment in the ‘twilight zone’
по: Hill, J, и др.
Опубликовано: (2013)

GAT: a simulation framework for testing the association of genomic intervals
по: Heger, A, и др.
Опубликовано: (2013)

Whole-genome analysis of the transcriptional network underlying male sexual behaviour in Drosophila melanogaster
по: Ashley, E, и др.
Опубликовано: (2012)

Accessing complex genomic variation in Plasmodium falciparum natural infections
по: Wendler, J
Опубликовано: (2015)

Increasing statistical power and generalizability in genomics microarray research
по: Ramasamy, A
Опубликовано: (2009)

The evolutionary dynamics of neutral networks: lessons from RNA
по: Rendel, M
Опубликовано: (2008)

Statistical models for single-cell data
по: Pierson, E
Опубликовано: (2015)