Characterizing the free-energy landscapes of DNA origamis

We show how coarse-grained modelling combined with umbrella sampling using distance-based order parameters can be applied to compute the free-energy landscapes associated with mechanical deformations of large DNA nanostructures. We illustrate this approach for the strong bending of DNA nanotubes and...

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Príomhchruthaitheoirí: Wong, CK, Tang, C, Schreck, JS, Doye, JPK
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Royal Society of Chemistry 2022