Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is...
| Main Authors: | , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2005
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