Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Abdi, K, Singh, N, Spooner, E, Kessler, B, Radaev, S, Lantz, L, Xiao, T, Matzinger, P, Sun, P, Ploegh, H
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	American Association of Immunologists 2014

Ижил төстэй зүйлс

IL-12p40 Monomer: A Potential Player in Macrophage Regulation
-н: Brian Jeong, зэрэг
Хэвлэсэн: (2024-02-01)

IL-15 promotes polyfunctional NK cell responses to influenza by boosting IL-12 production
-н: Wagstaffe, HR, зэрэг
Хэвлэсэн: (2018)

Inhibition of IL-12 heterodimers impairs TLR9-mediated prevention of early mouse plasmacytoma cell growth
-н: Mohamed F. Mandour, зэрэг
Хэвлэсэн: (2023-01-01)

1214 IL-12 vectors engineered to encode a functional p35-p40 heterodimer or a single p35 subunit for cancer immunotherapy
-н: Robert Johnson, зэрэг
Хэвлэсэн: (2023-11-01)

A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
-н: Khanh T.P. Nguyen, зэрэг
Хэвлэсэн: (2022-10-01)

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity
-н: Wei Chen, зэрэг
Хэвлэсэн: (2020-05-01)

Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis
-н: Jun-Su Zhou, зэрэг
Хэвлэсэн: (2024-07-01)

Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer
-н: Madhuchhanda Kundu, зэрэг
Хэвлэсэн: (2022-01-01)

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
-н: Mingli Xu, зэрэг
Хэвлэсэн: (2010-01-01)

The Impact of Genetic Variants in IL-10 and IL-12p40 on the Susceptibility to Non Hodgkin Lymphoma
-н: Mayasa Abdulla Ali, зэрэг
Хэвлэсэн: (2019-06-01)

The level of cytokines IL-4, IL-12p40, IFN-y during acute toxoplasmosis
-н: Dina A. Abdullah, зэрэг
Хэвлэсэн: (2012-01-01)

The Impact of Genetic Variants in IL-10 and IL-12p40 on the Susceptibility to Non Hodgkin Lymphoma
-н: Mayasa Abdulla Ali, зэрэг
Хэвлэсэн: (2019-06-01)

IL-12/IL-23p40 identified as a downstream target of apremilast in models of arthritis
-н: Tue W. Kragstrup, зэрэг
Хэвлэсэн: (2019-02-01)

Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers
-н: Tao Bing, зэрэг
Хэвлэсэн: (2019-06-01)

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
-н: Gaëlle Chognard, зэрэг
Хэвлэсэн: (2014-01-01)

Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter
-н: Tapmeier, T, зэрэг
Хэвлэсэн: (2004)

Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression <it>in vivo</it>
-н: Flynn Marion A, зэрэг
Хэвлэсэн: (2004-10-01)

Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth
-н: Svetlana A. Mikheeva, зэрэг
Хэвлэсэн: (2024-03-01)

IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity
-н: Koji Tatebayashi, зэрэг
Хэвлэсэн: (2005-01-01)

IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes.
-н: Michael P Crawford, зэрэг
Хэвлэсэн: (2023-01-01)

IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice
-н: Menglin Liu, зэрэг
Хэвлэсэн: (2022-09-01)

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity
-н: Aikaterini Kyriakou, зэрэг
Хэвлэсэн: (2014-01-01)

Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma
-н: Malin Nilsson, зэрэг
Хэвлэсэн: (2024-05-01)

Ebola virus protein VP40 stimulates IL-12– and IL-18–dependent activation of human natural killer cells
-н: Hung Le, зэрэг
Хэвлэсэн: (2022-08-01)

Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation.
-н: Bibiana Bielekova, зэрэг
Хэвлэсэн: (2012-01-01)

Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum.
-н: Anna Nolan, зэрэг
Хэвлэсэн: (2013-01-01)

Evaluation of Salivary Interleukin 2 (IL-2) and Interleukin 12(IL-12) in Recurrent Aphthous Stomatitis
-н: Sura Farhan Saeed, зэрэг
Хэвлэсэн: (2024-10-01)

IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
-н: Peng, Judy C., зэрэг
Хэвлэсэн: (2006)

A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers
-н: Yılmaz Yücehan Yazıcı, зэрэг
Хэвлэсэн: (2023-01-01)

The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis.
-н: Amir Abushouk, зэрэг
Хэвлэсэн: (2019-04-01)

The multifaceted role of IL-12 in cancer
-н: Um e Habiba, зэрэг
Хэвлэсэн: (2022-10-01)

Disseminated Mycobacterium simiae Infection in a Patient with Complete IL-12p40 Deficiency
-н: Seyed Alireza Mahdaviani, зэрэг
Хэвлэсэн: (2021-06-01)

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8
-н: Jonatas do Amaral, зэрэг
Хэвлэсэн: (2023-01-01)

IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt
-н: Renée H. Fiechter, зэрэг
Хэвлэсэн: (2021-03-01)

The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
-н: Abrar Kareem Dhari, зэрэг
Хэвлэсэн: (2024-10-01)

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15
-н: Abdolkarim Sheikhi, зэрэг
Хэвлэсэн: (2016-09-01)

IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.
-н: Horwood, N, зэрэг
Хэвлэсэн: (2001)

Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
-н: A. Khoshdel, зэрэг

IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.
-н: Lara R Mittereder, зэрэг
Хэвлэсэн: (2023-01-01)

Evaluation of serum level of IL-12 in patients with
-н: Mohammad Kazemi Arababadi1, зэрэг
Хэвлэсэн: (2009-01-01)