Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...

书目详细资料
Main Authors:	Abdi, K, Singh, N, Spooner, E, Kessler, B, Radaev, S, Lantz, L, Xiao, T, Matzinger, P, Sun, P, Ploegh, H
格式:	Journal article
语言:	English
出版:	American Association of Immunologists 2014

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