Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

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Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplaine...

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Detalles Bibliográficos
Autores principales: Henry, A, Roselli, C, Lin, H, Sveinbjörnsson, G, Fatemifar, G, Hedman, AK, Wilk, JB, Morley, MP, Chaffin, MD, Helgadottir, A, Verweij, N, Dehghan, A, Almgren, P, Andersson, C, Aragam, KG, Ärnlöv, J, Backman, JD, Biggs, ML, Bloom, HL, Shah, S, Graciela E Delgado, Vilmantas Giedraitis, Brandimarto, J, Brown, MR, Buckbinder, L, Carey, DJ, Chasman, DI, Chen, X, Chung, J, Chutkow, W, Cook, JP, Denaxas, S, Doney, AS, Dörr, M, Dudley, SC, Dunn, ME, Engström, G, Esko, T, Felix, SB, Finan, C, Ford, I, Ghanbari, M, Ghasemi, S, Giulianini, F, Gottdiener, JS, Gross, S, Guðbjartsson, DF, Gutmann, R, Haggerty, CM
Formato: Journal article
Lenguaje:English
Publicado: Springer Nature 2020

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