Asymmetric Induction in C-Alkylation of Tropane-Derived Enamines: Congruence Between Computation and Experiment
Quantum chemical studies of C-ethylation of 1-methyl- and 1,4,4-trimethyl-tropane-derived enamines predict good (89:11 er, B3LYP) and high (98:2 er, B3LYP) levels, respectively, of asymmetric induction in the resulting α-alkylated aldehydes. The non-racemic tropanes were synthesized using Mannich cy...
| Główni autorzy: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Wydane: |
American Chemical Society
2017
|