A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo.

We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein (NP) epitope, amino acid sequence ASNENMDAM, is fused to mouse beta(2)-microglobulin and the D(b) H chain via flexible linker sequences. This single-chain trimer (SCT) w...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Palmowski, M, Parker, M, Choudhuri, K, Chiu, C, Callan, M, Van Der Merwe, P, Cerundolo, V, Gould, K
Format: Journal article
Język:English
Wydane: 2009