Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylate...

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Những tác giả chính: Buss, H, Handschick, K, Jurrmann, N, Pekkonen, P, Beuerlein, K, Müller, H, Wait, R, Saklatvala, J, Ojala, P, Schmitz, M, Naumann, M, Kracht, M
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Public Library of Science 2012

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