Integration and validation of host transcript signatures, including a novel 3-transcript tuberculosis signature, to enable one-step multiclass diagnosis of childhood febrile disease

Background: Whole blood host transcript signatures show great potential for diagnosis of infectious and inflammatory illness, with most published signatures performing binary classification tasks. Barriers to clinical implementation include validation studies, and development of strategies that enab...

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Main Authors: Channon-Wells, S, Habgood-Coote, D, Vito, O, Galassini, R, Wright, VJ, Brent, AJ, Heyderman, RS, Anderson, ST, Eley, B, Martinón-Torres, F, Levin, M, Kaforou, M, Herberg, JA
Format: Journal article
Language:English
Published: BioMed Central 2024