Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.

Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4(+) T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4(+) T cells resulting in productive infection. Transmission takes place ac...

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Príomhchruthaitheoirí: Groot, F, Welsch, S, Sattentau, Q
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2008