Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein coupled receptor promotes senescence in synovial fibrob...

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Bibliographic Details
Main Authors: Montero-Melendez, T, Nagano, A, Chelala, C, Filer, A, Buckley, CD, Perretti, M
Format: Journal article
Language:English
Published: Nature Research 2020