Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein coupled receptor promotes senescence in synovial fibrob...

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書目詳細資料
Main Authors: Montero-Melendez, T, Nagano, A, Chelala, C, Filer, A, Buckley, CD, Perretti, M
格式: Journal article
語言:English
出版: Nature Research 2020