Notch signalling drives synovial fibroblast identity and arthritis pathology

The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint. It has recently been shown that a subset of fibr...

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Библиографические подробности
Главные авторы: Wei, K, Korsunsky, I, Marshall, JL, Gao, A, Watts, GFM, Major, T, Croft, AP, Watts, J, Blazar, P, Lange, J, Thornholl, T, Filer, A, Raza, K, Donlin, LT, Siebel, CW, Buckley, C, Raychaudhuri, S, Brenner, MB
Другие авторы: Accelerating Medicines Partnership-Rheumatoid Arthritis/Systemic Lupus Erythematosus (Amp Ra/Sle)
Формат: Journal article
Язык:English
Опубликовано: Springer Nature 2020