Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.

The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the...

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Bibliographic Details
Main Authors: Zheng, S, Moehlenbrink, J, Lu, Y, Zalmas, L, Sagum, C, Carr, S, McGouran, J, Alexander, L, Fedorov, O, Munro, S, Kessler, B, Bedford, M, Yu, Q, La Thangue, N
Format: Journal article
Language:English
Published: 2013