Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.

Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.

Local adenoviral (Ad)-mediated gene transfer to the carotid artery of the stroke-prone spontaneously hypertensive rat (SHRSP) is successful in improving endothelial function. Here we explored the potential of systemic delivery of Ad encoding endothelial nitric oxide synthase (AdeNOS) to prevent elev...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Miller, W, Brosnan, M, Graham, D, Nicol, C, Morecroft, I, Channon, K, Danilov, S, Reynolds, P, Baker, A, Dominiczak, A
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2005

Gelijkaardige items

Targeted delivery of adenovirus expressing eNOS to the endothelium in vivo lowers blood pressure in hypertensive rats
door: Miller, W, et al.
Gepubliceerd in: (2004)

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats.
door: Brosnan, M, et al.
Gepubliceerd in: (2002)

Sustained lowering of systolic blood pressure using an endothelial cell-targeted adenoviral vector
door: Miller, W, et al.
Gepubliceerd in: (2004)

Endothelial targeting of adenoviral vectors expressing eNOS lowers blood pressure in a rat model of genetic hypertension
door: Miller, W, et al.
Gepubliceerd in: (2004)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
door: Channon, K
Gepubliceerd in: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
door: Cai, S, et al.
Gepubliceerd in: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
door: Cai, S, et al.
Gepubliceerd in: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
door: Alp, N, et al.
Gepubliceerd in: (2004)

Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology.
door: Li, Y, et al.
Gepubliceerd in: (2005)

Functional assessment of the endothelial nitric oxide synthase Glu298Asp polymorphism
door: McDonald, D, et al.
Gepubliceerd in: (2002)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
door: Crabtree, M, et al.
Gepubliceerd in: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
door: Crabtree, M, et al.
Gepubliceerd in: (2011)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
door: Alp, N, et al.
Gepubliceerd in: (2004)

Tetrahydrobiopterin and nitric oxide synthase recouplers
door: Channon, KM
Gepubliceerd in: (2020)

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
door: McDonald, D, et al.
Gepubliceerd in: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
door: Khoo, J, et al.
Gepubliceerd in: (2005)

Adenoviral-mediated systemic administration of candidate therapeutic genes in a model of genetic hypertension
door: Miller, W, et al.
Gepubliceerd in: (2003)

Caveolin-1/Endothelial Nitric Oxide Synthase Interaction Is Reduced in Arteries From Pregnant Spontaneously Hypertensive Rats
door: Jéssica A. Troiano, et al.
Gepubliceerd in: (2021-11-01)

Systemic gene transfer of oxidant stress genes and blood pressure in a model of genetic hypertension
door: Miller, W, et al.
Gepubliceerd in: (2003)

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
door: Antoniades, C, et al.
Gepubliceerd in: (2009)

Endothelial nitric oxide synthase and heart rate.
door: Herring, N, et al.
Gepubliceerd in: (2002)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
door: V. P. Deryagina, et al.
Gepubliceerd in: (2021-07-01)

Targeting and translocation of endothelial nitric oxide synthase
door: T. Michel
Gepubliceerd in: (1999-11-01)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
door: Cai, S, et al.
Gepubliceerd in: (2005)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
door: Juni, R, et al.
Gepubliceerd in: (2012)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
door: Chiara De Luca, et al.
Gepubliceerd in: (2015-01-01)

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
door: Cai, S, et al.
Gepubliceerd in: (2005)

Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
door: Guzik, T, et al.
Gepubliceerd in: (2001)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
door: Cai, S, et al.
Gepubliceerd in: (2004)

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
door: Andy W. C. Man, et al.
Gepubliceerd in: (2022-07-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
door: Crabtree, M, et al.
Gepubliceerd in: (2013)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
door: Khoo, J, et al.
Gepubliceerd in: (2005)

Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
door: Antoniades, C, et al.
Gepubliceerd in: (2008)

Neuronal and endothelial nitric oxide synthase gene knockout mice
door: P.L. Huang
Gepubliceerd in: (1999-11-01)

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia
door: Paul Guerby, et al.
Gepubliceerd in: (2019-04-01)

Evaluation of Endothelial Nitric Oxide Synthase and Nitric Oxide Levels in Preeclamptic and Normotensive Pregnant Women
door: Rajeev Gandham, et al.
Gepubliceerd in: (2021-01-01)

Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels
door: Chaichanabut C, et al.
Gepubliceerd in: (2024-04-01)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
door: Khoo, J, et al.
Gepubliceerd in: (2004)

Effects of endothelial nitric oxide synthase on mouse arteriovenous fistula hemodynamics
door: Shelly Baltazar, et al.
Gepubliceerd in: (2023-12-01)

Post-translational Regulation of Endothelial Nitric Oxide Synthase in Vascular Endothelium
door: Jin eQian, et al.
Gepubliceerd in: (2013-12-01)