Advances in the 5q- syndrome.

Advances in the 5q- syndrome.

The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during recent years has been based on the determination of the commonly deleted region and the demonstration of haploinsufficiency for the ribosomal...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Boultwood, J, Pellagatti, A, McKenzie, A, Wainscoat, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2012)

RECENT ADVANCES IN THE 5Q- SYNDROME
gan: Andrea Pellagatti, et al.
Cyhoeddwyd: (2015-05-01)

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2012)

The 5q-syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (1994)

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2010)

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2013)

The 5q- syndrome.
gan: Giagounidis, A, et al.
Cyhoeddwyd: (2004)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2011)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2011)

Gene expression profiling in 5q-syndrome and myelodysplastic syndromes.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2003)

MOLECULAR DELINEATION OF THE CRITICAL REGION OF THE 5Q-CHROMOSOME IN THE 5Q-SYNDROME
gan: Boultwood, J, et al.
Cyhoeddwyd: (1993)

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome.
gan: Fidler, C, et al.
Cyhoeddwyd: (1999)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q)
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2005)

Lenalidomide selectively inhibits in vitro growth of the malignant clone in myelodysplastic syndrome (MDS) patients with 5q deletion.
gan: Jadersten, M, et al.
Cyhoeddwyd: (2005)

Gene expression profiling in the myelodysplastic syndromes.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2005)

Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q- syndrome: delineation of the critical region on 5q and identification of a 5q- breakpoint.
gan: Boultwood, J, et al.
Cyhoeddwyd: (1994)

MOLECULAR MAPPING OF UNCHARACTERISTICALLY SMALL 5Q DELETIONS IN 2 PATIENTS WITH THE 5Q- SYNDROME - DELINEATION OF THE CRITICAL REGION ON 5Q AND IDENTIFICATION OF A 5Q- BREAKPOINT
gan: Boultwood, J, et al.
Cyhoeddwyd: (1993)

Effects of L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
gan: Yip, B, et al.
Cyhoeddwyd: (2012)

Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
gan: Yip, B, et al.
Cyhoeddwyd: (2012)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q).
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2004)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression.
gan: Jädersten, M, et al.
Cyhoeddwyd: (2009)

SF3B1 mutant myelodysplastic syndrome: Recent advances
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2020)

ISOLATION OF NOVEL CDNA CLONES MAPPING TO THE CRITICAL REGION OF THE 5Q-CHROMOSOME IN THE 5Q-SYNDROME
gan: Boultwood, J, et al.
Cyhoeddwyd: (1994)

Homozygous deletion of FMS in a patient with the 5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (1990)

Narrowing and genomic annotation of the critical region of the 5q-syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2000)

Gene expression profiling of CD34+ cells in patients with the 5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2007)

Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2008)

Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2000)

Molecular analysis of the 5q-syndrome
gan: Boultwood, J
Cyhoeddwyd: (2007)

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.
gan: Barlow, J, et al.
Cyhoeddwyd: (2010)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.
gan: Fernandez-Mercado, M, et al.
Cyhoeddwyd: (2013)

Combined immunophenotyping and FISH identifies the involvement of B-cells in 5q- syndrome.
gan: Jaju, R, et al.
Cyhoeddwyd: (2000)

Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
gan: Yip, B, et al.
Cyhoeddwyd: (2013)

NRAS, FLT3 and TP53 mutations in patients with myelodysplastic syndrome and a del(5q).
gan: Fidler, C, et al.
Cyhoeddwyd: (2004)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression
gan: Martin Jädersten, et al.
Cyhoeddwyd: (2009-12-01)

Activation of the mTOR signaling pathway by L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
gan: Yip, B, et al.
Cyhoeddwyd: (2013)

Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (2002)

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome.
gan: Boultwood, J, et al.
Cyhoeddwyd: (1993)

Lenalidomide up-regulates SPARC and inhibits in vitro growth of the malignant clone in myelodysplastic syndrome patients with 5q deletion.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2006)

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.
gan: Pellagatti, A, et al.
Cyhoeddwyd: (2007)