Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin process...

Full description

Bibliographic Details
Main Authors: Dimas, A, Lagou, V, Barker, A, Knowles, J, Mägi, R, Hivert, M, Benazzo, A, Rybin, D, Jackson, A, Stringham, H, Song, C, Fischer-Rosinsky, A, Boesgaard, T, Grarup, N, Abbasi, F, Assimes, T, Hao, K, Yang, X, Lecoeur, C, Barroso, I, Bonnycastle, L, Böttcher, Y, Bumpstead, S, Chines, P, Erdos, MR
Format: Journal article
Language:English
Published: 2014