Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Targeting specific protein-protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. A potential solution to these problems is to s...

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Bibliographic Details
Main Authors: Quevedo, C, Cruz-Migoni, A, Bery, N, Miller, A, Tanaka, T, Petch, D, Bataille, C, Lee, L, Fallon, P, Tulmin, H, Ehebauer, M, Fernandez-Fuentes, N, Russell, A, Carr, S, Phillips, S, Rabbitts, T
Format: Journal article
Language:English
Published: Springer Nature 2018