Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.

Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.

Import of exogenous plasmid DNA (pDNA) into mammalian cell nuclei represents a key intracellular obstacle to efficient non-viral gene delivery. This includes access of the pDNA to the nuclei of non-dividing cells where the presence of an intact nuclear membrane is limiting for gene transfer. Here we...

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Hlavní autoři: Munkonge, F, Amin, V, Hyde, S, Green, A, Pringle, I, Gill, DR, Smith, J, Hooley, R, Xenariou, S, Ward, M, Leeds, N, Leung, K, Chan, M, Hillery, E, Geddes, D, Griesenbach, U, Postel, E, Dean, D, Dunn, M, Alton, E
Médium: Journal article
Jazyk:English
Vydáno: 2009

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