Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.

Mutations at the hMSH2 and hMLH1 mismatch repair loci have been implicated in the pathogenesis of colorectal cancer. Tumours with two allelic mutations at a mismatch repair locus develop replication errors (RERs). In the hereditary non-polyposis colorectal cancer (HNPCC) syndrome, one mutation is in...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Tomlinson, I, Ilyas, M, Bodmer, W
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	1996

Những quyển sách tương tự

Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability.
Bằng: Catto, J, et al.
Được phát hành: (2003)

The association between genetic variants in <it>hMLH1 </it>and <it>hMSH2 </it>and the development of sporadic colorectal cancer in the Danish population
Bằng: Syvänen Ann-Christine, et al.
Được phát hành: (2008-06-01)

Germline mutations in the mismatch repair genes hMLH1 and hMSH2 may predispose to the formation of multiple adenomatous polyps
Bằng: Fearnhead, N, et al.
Được phát hành: (2002)

Prevalence of pathological germline mutations of hMLH1 and hMSH2 genes in colorectal cancer.
Bằng: Dandan Li, et al.
Được phát hành: (2013-01-01)

Aberrantly Methylated MGMT, hMLH1 and hMSH2 in Tumor and Serum DNA of Gliomas Patients
Bằng: Chanqing ZHENG, et al.
Được phát hành: (2009-02-01)

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
Bằng: Dmitry José de Santana Sarmento, et al.
Được phát hành: (2016-08-01)

hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer.
Bằng: Kim, J, et al.
Được phát hành: (2001)

Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China population.
Bằng: Fulan Hu, et al.
Được phát hành: (2013-01-01)

Prognostic value of p53, hMLH1, hMSH2, MGMT and COX-2 in the QUASAR-1 Dukes' stage B colorectal cancer cohort
Bằng: Jubb, A, et al.
Được phát hành: (2002)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers.
Bằng: Wheeler, J, et al.
Được phát hành: (2000)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers
Bằng: Wheeler, J, et al.
Được phát hành: (2000)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus sporadic RER plus colorectal cancers
Bằng: Wheeler, J, et al.
Được phát hành: (2000)

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
Bằng: Wheeler, J, et al.
Được phát hành: (1999)

Detección de mutaciones de los genes hMLH1 y hMSH2 del sistema de reparación de malos apareamientos del ADN en familias colombianas sospechosas de cancer colorrectal no polipósico hereditario (síndrome de Lynch).
Bằng: Andrea Gómez, et al.
Được phát hành: (2005-09-01)

HOXA5 Regulates hMLH1 Expression in Breast Cancer Cells
Bằng: Sai Duriseti, et al.
Được phát hành: (2006-04-01)

MutS homologue hMSH5: role in cisplatin-induced DNA damage response
Bằng: Tompkins Joshua D, et al.
Được phát hành: (2012-03-01)

Mutations in <it>APC</it>, <it>CTNNB1 </it>and <it>K-ras </it>genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
Bằng: de Bruïne Adriaan P, et al.
Được phát hành: (2005-12-01)

The hMLH1 -93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population.
Bằng: Leilei Niu, et al.
Được phát hành: (2015-01-01)

Expression of the hMSH6 mismatch-repair protein in colon cancer and HeLa cells
Bằng: H Klingler, et al.
Được phát hành: (2002-02-01)

MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.
Bằng: Xiling Wu, et al.
Được phát hành: (2013-01-01)

HUBUNGAN EKSPRESI p53 DAN hMLH1 DENGAN KARAKTERISTIK KLINIKOPATOLOGIK KARSINOMA KOLOREKTAL
Bằng: , PIERI KUMALADEWI, et al.
Được phát hành: (2013)

Correction: The hMLH1 -93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population.
Bằng: Leilei Niu, et al.
Được phát hành: (2019-01-01)

Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis
Bằng: Peng Ye, et al.
Được phát hành: (2018-04-01)

错配修复蛋白hMLH1在子宫内膜癌表达的临床意义
Bằng: 林美芳
Được phát hành: (2005-01-01)

Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations.
Bằng: Mei Li, et al.
Được phát hành: (2013-01-01)

<it>MSH2 </it>and <it>MLH1 </it>testing
Bằng: Kurzawski Grzegorz, et al.
Được phát hành: (2008-06-01)

Imunoexpressão da proteína de reparo hMSH2 em queilite actínica e mucosa labial normal
Bằng: Hélder Antônio Rebelo Pontes, et al.
Được phát hành: (2005-03-01)

hMSH2 coordinated with the expression of E2F1 promotes platinum response in epithelial ovarian cancer
Bằng: Xiao-qian Hu, et al.
Được phát hành: (2023-03-01)

Allele loss on chromosome 11q and microsatellite instability in malignant melanoma.
Bằng: Tomlinson, I, et al.
Được phát hành: (1996)

Frequency of gene hMLH1 promoter methylation in the stomach antral and body area tissue of chronic atrophic pangastritis patients
Bằng: Rita Kupčinskaitė-Noreikienė, et al.
Được phát hành: (2013-09-01)

错配修复基因产物hMSH2 在涎腺良恶性组织的表达
Bằng: 程　斌, et al.
Được phát hành: (2000-01-01)

Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells.
Bằng: Stephanie S Tseng-Rogenski, et al.
Được phát hành: (2012-01-01)

Alteration of P53, hMLH1, and HER2 Gene in Bangladeshi Gastric Cancer Patients: Their Association with H. pylori Infection and Clinicopathological Factors
Bằng: M. Mizanur Rahman, et al.
Được phát hành: (2021-07-01)

Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
Bằng: Ilyas, M, et al.
Được phát hành: (1996)

子宫内膜癌错配修复基因hMLH1的表达和启动子甲基化研究
Được phát hành: (2009-01-01)

EBV-Infection in Cardiac and Non-Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1
Bằng: Helene Geddert, et al.
Được phát hành: (2010-01-01)

Microsatellite instability and the clinicopathological features of sporadic colorectal cancer.
Bằng: Ward, R, et al.
Được phát hành: (2001)

Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers
Bằng: Fen Wu, et al.
Được phát hành: (2013-02-01)

miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2
Bằng: Ling Ye, et al.
Được phát hành: (2017-06-01)

Expression of MLH-1, PMS-2, MSH-2, MSH-6 markers and histopathological evaluation in colorectal cancer
Bằng: Syed Ali Baqher Hussaini, et al.
Được phát hành: (2024-07-01)