How much fat is necessary to optimize lumefantrine oral bioavailability?

How much fat is necessary to optimize lumefantrine oral bioavailability?

BACKGROUND: Artemether-lumefantrine (AL) is the only fixed, artemisinin-based combination antimalarial drug which is registered internationally and deployed on a large scale. Absorption of the hydrophobic lipophilic lumefantrine component varies widely between individuals and is greatly increased b...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Ashley, E, Stepniewska, K, Lindegårdh, N, Annerberg, A, Kham, A, Brockman, A, Singhasivanon, P, White, N, Nosten, F
Format:	Journal article
Sprache:	English
Veröffentlicht:	2007

Ähnliche Einträge

Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
von: Tarning, J, et al.
Veröffentlicht: (2009)

Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.
von: Ashley, E, et al.
Veröffentlicht: (2007)

Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
von: Ashley, E, et al.
Veröffentlicht: (2007)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
von: Mcgready, R, et al.
Veröffentlicht: (2006)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
von: McGready, R, et al.
Veröffentlicht: (2009)

Erratum:The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria(European Journal of Clinical Pharmacology (2006) 62 (1021-1031) DOI: 10.1007/s00228-006-0199-7)
von: Mcgready, R, et al.
Veröffentlicht: (2009)

A small amount of fat does not affect piperaquine exposure in patients with malaria.
von: Annerberg, A, et al.
Veröffentlicht: (2011)

A small amount of fat does not affect piperaquine exposure in patients with malaria.
von: Annerberg, A, et al.
Veröffentlicht: (2011)

Population pharmacokinetic assessment of the effect of food on piperaquine bioavailability in patients with uncomplicated malaria.
von: Tarning, J, et al.
Veröffentlicht: (2014)

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.
von: Ashley, E, et al.
Veröffentlicht: (2010)

High throughput assay for the determination of lumefantrine in plasma.
von: Annerberg, A, et al.
Veröffentlicht: (2005)

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
von: Ashley, E, et al.
Veröffentlicht: (2010)

A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand.
von: Hutagalung, R, et al.
Veröffentlicht: (2005)

Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.
von: Price, R, et al.
Veröffentlicht: (2006)

Development and validation of an automated solid-phase extraction and liquid chromatographic method for determination of lumefantrine in capillary blood on sampling paper.
von: Blessborn, D, et al.
Veröffentlicht: (2007)

A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy.
von: Mcgready, R, et al.
Veröffentlicht: (2008)

A case-control auditory evaluation of patients treated with artemether-lumefantrine.
von: Hutagalung, R, et al.
Veröffentlicht: (2006)

Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
von: Denis, M, et al.
Veröffentlicht: (2006)

Population pharmacokinetics and pharmacodynamics of artemether and lumefantrine in combination treatment of uncomplicated falciparum malaria in pediatric patients
von: Hietala, S, et al.
Veröffentlicht: (2009)

Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria.
von: van Vugt, M, et al.
Veröffentlicht: (2000)

Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.
von: Mwesigwa, J, et al.
Veröffentlicht: (2010)

Population pharmacokinetics and pharmacodynamics of artemether and lumefantrine during combination treatment in children with uncomplicated falciparum malaria in Tanzania.
von: Hietala, S, et al.
Veröffentlicht: (2010)

How Much DC Power Is Necessary?
von: Leeb, Steven B., et al.
Veröffentlicht: (2012)

A randomized trial of artemether-lumefantrine <it>versus </it>mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant <it>Plasmodium falciparum </it>on the western border of Thailand
von: McGready Rose, et al.
Veröffentlicht: (2005-09-01)

A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy.
von: Rose McGready, et al.
Veröffentlicht: (2008-12-01)

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats
von: Wahajuddin, et al.
Veröffentlicht: (2011-10-01)

Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.
von: Mayxay, M, et al.
Veröffentlicht: (2004)

Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria.
von: Vugt, M, et al.
Veröffentlicht: (1999)

Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects.
von: Mcgready, R, et al.
Veröffentlicht: (2012)

Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
von: Kloprogge, F, et al.
Veröffentlicht: (2013)

Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated Plasmodium falciparum malaria in Luang Namtha Province, Lao People's Democratic Republic.
von: Stohrer, J, et al.
Veröffentlicht: (2004)

Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria.
von: Ashley, E, et al.
Veröffentlicht: (2006)

Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria.
von: Ezzet, F, et al.
Veröffentlicht: (2000)

Development and validation of a bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma.
von: Lindeg?rdh, N, et al.
Veröffentlicht: (2005)

The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.
von: Chotivanich, K, et al.
Veröffentlicht: (2012)

Foot orthoses: how much customisation is necessary?
von: Menz Hylton B
Veröffentlicht: (2009-07-01)

Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.
von: Färnert, A, et al.
Veröffentlicht: (2012)

Lumefantrine and desbutyl-lumefantrine population pharmacokinetic-pharmacodynamic relationships in pregnant women with uncomplicated Plasmodium falciparum malaria on the Thailand-Myanmar border
von: Kloprogge, F, et al.
Veröffentlicht: (2015)

Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects.
von: Lindegardh, N, et al.
Veröffentlicht: (2008)

Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine.
von: Ali, S, et al.
Veröffentlicht: (2010)