A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.

A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.

In order to incorporate human cardiac troponin I (TnI) and troponin C (TnC) into guinea pig skinned cardiac trabeculae, fibres were treated with vanadate to extract endogenous TnI and TnC using established protocols. After addition of human TnI and TnC force was inadequately restored and it was foun...

Descripció completa

Dades bibliogràfiques
Autors principals:	Preston, L, Watkins, H, Redwood, C
Format:	Journal article
Idioma:	English
Publicat:	2006

Ítems similars

The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin
per: Redwood, C, et al.
Publicat: (2001)

The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A
per: Van Der Velden, J, et al.
Publicat: (2012)

Mechanical effects of human cardiac troponin C mutation Gly159Asp in exchanged rabbit psoas fibres
per: Preston, L, et al.
Publicat: (2004)

Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
per: Robinson, P, et al.
Publicat: (2007)

The HCM-Associated Cardiac Troponin T Mutation K280N Increases the Energetic Cost of Tension Generation in Human Cardiac Myofibrils
per: Ferrara, C, et al.
Publicat: (2013)

Altered inhibitory and troponin C-binding activities in cardiac troponin I mutants known to cause hypertrophic cardiomyopathy
per: Elliott, K, et al.
Publicat: (2000)

Investigating the Effect of Cardiomyopathy-Causing Mutations in Cardiac Troponin-T on Calcium Buffering In Situ
per: Robinson, P, et al.
Publicat: (2010)

Dilated cardiomyopathy causing mutations in cardiac troponin T (TNT), cardiac troponin C (TNC), and alpha tropomyosin (TM) reduce CA(2+) sensitivity and maximum calcium activation
per: Redwood, C, et al.
Publicat: (2004)

Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart
per: Bayliss, C, et al.
Publicat: (2012)

DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation.
per: Preston, L, et al.
Publicat: (2007)

Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
per: Burton, D, et al.
Publicat: (2002)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
per: Robinson, P, et al.
Publicat: (2007)

Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy
per: Abdulrazzak, H, et al.
Publicat: (2001)

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.
per: Elliott, K, et al.
Publicat: (2000)

Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy
per: Robinson, P, et al.
Publicat: (2003)

Two mutations in human cardiac troponin I known to cause hypertrophic cardiomyopathy have different effects on cardiac muscle contraction
per: Burton, D, et al.
Publicat: (2000)

Mutations in fast skeletal troponin I, troponin T and beta-tropomyosin that cause distal arthrogryposis all enhance thin filament activation
per: Robinson, P, et al.
Publicat: (2005)

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
per: Burton, D, et al.
Publicat: (2002)

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy.
per: Mogensen, J, et al.
Publicat: (2004)

Clinical Utility of Cardiac Troponin I and Cardiac Troponin T Measurements
per: Michaela Adamcová, et al.
Publicat: (1997-01-01)

Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies
per: Robinson, P, et al.
Publicat: (2002)

Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T
Publicat: (2006-03-01)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
per: Robinson, P, et al.
Publicat: (2007)

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.
per: Robinson, P, et al.
Publicat: (2002)

Cardiac troponin I is a potential novel substrate for AMP-activated protein kinase
per: Oliveira, S, et al.
Publicat: (2007)

Structure-function relationships of eight mutations in troponin and tropomyosin that cause dilated cardiomyopathy
per: Mirza, M, et al.
Publicat: (2004)

Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T
per: Shirin Akhter, et al.
Publicat: (2015-01-01)

Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin filament calcium binding
per: Robinson, P, et al.
Publicat: (2007)

In vitro motility studies of HCM and DCM mutations in cardiac muscle actin
per: Dyer, E, et al.
Publicat: (2007)

Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
per: Moolman-Smook, J, et al.
Publicat: (2001)

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation
per: Messer, A, et al.
Publicat: (2016)

HCM and DCM mutations in cardiac thin filament proteins have opposite effects on the regulation of contractility in vitro
per: Redwood, C, et al.
Publicat: (2003)

Investigating outlier rates of cardiac troponin I and troponin T assays: A systematic review
per: Litao Zhang, et al.
Publicat: (2024-01-01)

Troponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I
per: Hyoban Lee, et al.
Publicat: (2020-07-01)

Effects of troponin C isoform on the action of the cardiotonic agent EMD 57033.
per: Lipscomb, S, et al.
Publicat: (2005)

Identification and functional analysis of cardiac troponin I as a novel disease gene in autosomal dominant familial dilated cardiomyopathy
per: Carballo, S, et al.
Publicat: (2006)

Evidence for haploinsufficiency as the mechanism of action of MyBP-C mutations that cause HCM
per: Carballo, S, et al.
Publicat: (2008)

CHEMOTHERAPY CARDIOTOXICITY SCREENING WITH CARDIAC TROPONINS
per: O. V. Krikunova, et al.
Publicat: (2015-12-01)

Biology of Cardiac Troponins: Emphasis on Metabolism
per: Aleksey M. Chaulin
Publicat: (2022-03-01)

Cardiac troponin T in neonates with respiratory distress
per: Sameh S. Fahmey, et al.
Publicat: (2018-12-01)