Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously,...

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Bibliographic Details
Main Authors: Tanaka, M, Asada, M, Higashi, A, Nakamura, J, Oguchi, A, Tomita, M, Yamada, S, Asada, N, Takase, M, Okuda, T, Kawachi, H, Economides, A, Robertson, E, Takahashi, S, Sakurai, T, Goldschmeding, R, Muso, E, Fukatsu, A, Kita, T, Yanagita, M
Format: Journal article
Language:English
Published: 2010

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