A recurrent activating missense mutation in Waldenström macroglobulinemia affects the DNA binding of the ETS transcription factor SPI1 and enhances proliferation

A recurrent activating missense mutation in Waldenström macroglobulinemia affects the DNA binding of the ETS transcription factor SPI1 and enhances proliferation

The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA binding sequences and interaction with cofactors. They are regulated by extracellular clues and contribute to cellular processes, including proliferation and transformation. ETS genes are targeted through...

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Bibliographic Details
Main Authors: Roos-Weil, D, Decaudin, C, Armand, M, Della-Valle, V, Diop, M, Ghamlouch, H, Ropars, V, Herate, C, Lara, D, Durot, E, Haddad, R, Mylonas, E, Damm, F, Pflumio, F, Stoilova, B, Metzner, M, Elemento, O, Dessen, P, Camara-Clayette, V, Cosset, F, Verhoeyen, E, Leblond, V, Ribrag, V, Cornillet-Lefebvre, P, Rameau, P, Azar, N, Charlotte, F, Morel, P, Charbonnier, J, Vyas, P, Mercher, T, Aoufouchi, S, Droin, N, Guillouf, C, Nguyen-Khac, F, Bernard, O
Format: Journal article
Language:English
Published: American Association for Cancer Research 2019

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