First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase
We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP<inf>5</inf> mimics 5-PP-InsP <inf>5</inf> binding to the kinase domain of PPIP5K2;...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2012
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