Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled L-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltrans...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Harrison, PJ, Gable, K, Somashekarappa, N, Kelly, V, Clarke, DJ, Naismith, JH, Dunn, TM, Campopiano, DJ
פורמט:	Journal article
שפה:	English
יצא לאור:	American Society for Biochemistry and Molecular Biology 2019

פריטים דומים

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
מאת: Peter J. Harrison, et al.
יצא לאור: (2019-05-01)

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
מאת: Sandra Hoefgen, et al.
יצא לאור: (2022-10-01)

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria
מאת: Jonathan Padilla-Gómez, et al.
יצא לאור: (2022-08-01)

Serine Palmitoyltransferase, the First Step Enzyme in Sphingolipid Biosynthesis, Is Involved in Nonhost Resistance
מאת: Yoshihiro Takahashi, et al.
יצא לאור: (2009-01-01)

Preparation of HeLa Total Membranes and Assay of Lipid-inhibition of Serine Palmitoyltransferase Activity
מאת: Muthukumar Kannan, et al.
יצא לאור: (2020-06-01)

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
מאת: Andrew Kuo, et al.
יצא לאור: (2022-10-01)

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins
מאת: Carolin Körner, et al.
יצא לאור: (2024-08-01)

Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet
מאת: Monika Imierska, et al.
יצא לאור: (2022-03-01)

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]
מאת: Irina Gorshkova, et al.
יצא לאור: (2012-08-01)

Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
מאת: Agnieszka Mikłosz, et al.
יצא לאור: (2013-01-01)

Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction
מאת: Gerd Gleixner
יצא לאור: (2022-01-01)

Identification and Characterization of Carnitine Palmitoyltransferase 1 () Genes in Nile Tilapia,
מאת: Mehtap Bayır, et al.
יצא לאור: (2020-03-01)

Neonatal Carnitine Palmitoyltransferase II Deficiency: A Lethal Entity
מאת: Sushma Malik, et al.
יצא לאור: (2015-10-01)

A mini review of small-molecule inhibitors targeting palmitoyltransferases
מאת: Xiaotong Hu, et al.
יצא לאור: (2022-08-01)

Carnitine palmitoyltransferase-II deficiency: case presentation and review of the literature
מאת: Mccormick Benjamin J., et al.
יצא לאור: (2021-12-01)

Screening of Saccharomyces cerevisiae metabolite transporters by 13C isotope substrate labeling
מאת: Lyubomir Dimitrov Stanchev, et al.
יצא לאור: (2023-11-01)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
מאת: Kiran Kurmi, et al.
יצא לאור: (2018-02-01)

Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grasshopper Valanga nigricornis(burm.)
מאת: Lee, C. W., et al.
יצא לאור: (1983)

PP-050 Carnitine palmitoyltransferase I deficiency case reporting in Krasnodar region
מאת: Natalia Shatokhina, et al.
יצא לאור: (2024-07-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
מאת: Minxuan Xu, et al.
יצא לאור: (2023-12-01)

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach
מאת: Pushpa Raj Joshi, et al.
יצא לאור: (2020-04-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
מאת: Minxuan Xu, et al.
יצא לאור: (2023-10-01)

Analytical methods for stable isotope labeling to elucidate rapid auxin kinetics in Arabidopsis thaliana.
מאת: Qian Tang, et al.
יצא לאור: (2024-01-01)

Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes
מאת: Nils W. F. Meijer, et al.
יצא לאור: (2024-04-01)

Investigation on substrate specificity and catalytic activity of serine protease neuropsin
מאת: Masami Lintuluoto, et al.
יצא לאור: (2022-10-01)

Clinical and literature review of a case of myopathic form of carnitine palmitoyltransferase Ⅱ deficiency
מאת: LU Guangshuang, XIA Mingnong, CHENG Yun, HU Jie, LI Wenbo, ZHANG Fan, YANG Wu
יצא לאור: (2024-10-01)

Carnitne Palmitoyltransferase II Defciency, a Rare Cause of Rhabdomyolysis: A Case Report
מאת: Parisa Farshchi, et al.
יצא לאור: (2019-11-01)

Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts.
מאת: Min Yao, et al.
יצא לאור: (2015-01-01)

Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
מאת: K Ikewaki, et al.
יצא לאור: (1993-12-01)

Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro
מאת: Jason S. Wasserman, et al.
יצא לאור: (2023-06-01)

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters
מאת: Wang, M, et al.
יצא לאור: (2017)

Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice
מאת: Mikala M. Zelows, et al.
יצא לאור: (2023-12-01)

Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner
מאת: Joseph Choi, et al.
יצא לאור: (2024-12-01)

Stemona alkaloid derivative induce ferroptosis of colorectal cancer cell by mediating carnitine palmitoyltransferase 1
מאת: He Yang, et al.
יצא לאור: (2024-10-01)

Myopathy due to carnitine palmitoyltransferase II deficiency: updating genetic aspects of the first publication in Brazil
מאת: Paulo José Lorenzoni, et al.
יצא לאור: (2024-02-01)

Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
מאת: Yaqin Zhu, et al.
יצא לאור: (2023-06-01)

A surviving 24-month-old patient with neonatal-onset carnitine palmitoyltransferase II deficiency
מאת: Naohiro Ikeda, et al.
יצא לאור: (2017-06-01)

Synthesis of isotopically labelled cardiolipins
מאת: Duralski, A, et al.
יצא לאור: (1998)

SYNTHESIS OF ISOTOPICALLY LABELED UBIQUINONES
מאת: Duralski, A, et al.
יצא לאור: (1992)

The organic chemistry of isotopic labelling /
מאת: 204185 Hanson, James R.
יצא לאור: (2011)