ASYMMETRIC-SYNTHESIS OF THE TAXOL AND TAXOTERE C-13 SIDE-CHAINS
A practical and efficient asymmetric synthesis of the 3-benzoylamino-2- hydroxy-3-phenylpropionic acid derived side chain of the important anticancer agent taxol is described. The pivotal synthetic transformation relies upon the highly diastereoselective tandem lithium amide conjugate addition-elect...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1994
|