ASYMMETRIC-SYNTHESIS OF THE TAXOL AND TAXOTERE C-13 SIDE-CHAINS

ASYMMETRIC-SYNTHESIS OF THE TAXOL AND TAXOTERE C-13 SIDE-CHAINS

A practical and efficient asymmetric synthesis of the 3-benzoylamino-2- hydroxy-3-phenylpropionic acid derived side chain of the important anticancer agent taxol is described. The pivotal synthetic transformation relies upon the highly diastereoselective tandem lithium amide conjugate addition-elect...

Bibliografski detalji
Glavni autori:	Bunnage, M, Davies, S, Goodwin, C
Format:	Journal article
Jezik:	English
Izdano:	1994

Slični predmeti

ASYMMETRIC-SYNTHESIS OF HOMOCHIRAL SYN-3-PHENYLISOSERINE AND ANTI-3-PHENYLISOSERINE DERIVATIVES - A PRACTICAL STRATEGY FOR THE SYNTHESIS OF THE TAXOL C-13 SIDE-CHAIN
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