A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins

Gauging the systemic effects of non-synonymous single nucleotide polymorphisms (nsSNPs) is an important topic in the pursuit of personalized medicine. However, it is a non-trivial task to understand how a change at the protein structure level eventually affects a cell's behavior. This is becaus...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Cheng, T, Goehring, L, Jeffery, L, Lu, Y, Hayles, J, Novák, B, Bates, P
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Public Library of Science 2012