A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins

A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins

Gauging the systemic effects of non-synonymous single nucleotide polymorphisms (nsSNPs) is an important topic in the pursuit of personalized medicine. However, it is a non-trivial task to understand how a change at the protein structure level eventually affects a cell's behavior. This is becaus...

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Bibliographic Details
Main Authors:	Cheng, T, Goehring, L, Jeffery, L, Lu, Y, Hayles, J, Novák, B, Bates, P
Format:	Journal article
Language:	English
Published:	Public Library of Science 2012

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