A cell topography-based mechanism for ligand discrimination by the T cell receptor
The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In res...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
National Academy of Sciences
2019
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