CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

Transfer of CD45RB(high) CD4+ T cells to immune-deficient mice in the absence of regulatory T cells leads to a Th1-mediated colitis. In this study, we show that intestinal inflammation is characterized by a 15-fold increase in the number of CD134L+ (OX40L+)-activated DC in the mesenteric lymph nodes...

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Những tác giả chính: Malmström, V, Shipton, D, Singh, B, Al-Shamkhani, A, Puklavec, M, Barclay, N, Powrie, F
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2001

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