Formation of quaternary centers by copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents.
Pure and simple: Alkylzirconocenes generated in situ from simple alkenes are used in highly enantioselective copper-catalyzed 1,4-addition reactions to trisubstituted cyclic enones to generate quaternary centers. These reactions operate at room temperature under a range of conditions and tolerate ma...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2013
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