Themis2: setting the threshold for B-cell selection.
The strength of signal downstream of the B-cell receptor (BCR) determines the positive and negative selection of B cells. Expression of a functional BCR is required for the selection of immature B cells into the peripheral repertoire in the absence of antigen; but selection is also modulated by avid...
| Main Authors: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Nature Publishing Group
2017
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| Resumo: | The strength of signal downstream of the B-cell receptor (BCR) determines the positive and negative selection of B cells. Expression of a functional BCR is required for the selection of immature B cells into the peripheral repertoire in the absence of antigen; but selection is also modulated by avidity and affinity-dependent interactions with self and foreign antigens. These antigendependent events shape the B-cell repertoire during ontogeny, development and the response to pathogens, and generation of B-cell memory; however, the mechanisms underlying these processes are not very well understood. |
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