Germline-activating mutations in PIK3CD compromise B cell development and function

Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected individuals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these immune defec...

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Bibliographic Details
Main Authors:	Avery, DT, Kane, A, Nguyen, T, Lau, A, Nguyen, A, Lenthall, H, Payne, K, Shi, W, Brigden, H, French, E, Bier, J, Hermes, JR, Zahra, D, Sewell, WA, Butt, D, Elliott, M, Boztug, K, Meyts, I, Choo, S, Hsu, P, Wong, M, Berglund, LJ, Gray, P, O'Sullivan, M, Cole, T, Holland, SM, Ma, CS, Burkhart, C, Corcoran, LM, Phan, TG, Brink, R, Uzel, G, Deenick, EK, Tangye, SG
Format:	Journal article
Language:	English
Published:	Rockefeller University Press 2018

Germline-activating mutations in PIK3CD compromise B cell development and function

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