Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.

All 16 stereoisomeric N-methyl 5-(hydroxymethyl)-3,4-dihydroxyproline amides have been synthesized from lactones accessible from the enantiomers of glucuronolactone. Nine stereoisomers, including all eight with a (3R)-hydroxyl configuration, are low to submicromolar inhibitors of β-N-acetylhexosamin...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Ayers, B, Glawar, A, Martínez, R, Ngo, N, Liu, Z, Fleet, G, Butters, T, Nash, R, Yu, C, Wormald, M, Nakagawa, S, Adachi, I, Kato, A, Jenkinson, S
Format: Journal article
Język:English
Wydane: 2014