Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.

Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative v...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: French, J, Ghoussaini, M, Edwards, S, Meyer, K, Michailidou, K, Ahmed, S, Khan, S, Maranian, M, O'Reilly, M, Hillman, K, Betts, J, Carroll, T, Bailey, P, Dicks, E, Beesley, J, Tyrer, J, Maia, A, Beck, A, Knoblauch, N, Chen, C, Kraft, P, Barnes, D, González-Neira, A, Alonso, MR, Herrero, D
Format: Journal article
Sprog:English
Udgivet: 2013