Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

Neisseria meningitidis protects itself from complement-mediated killing by binding complement factor H (FH). Previous studies associated susceptibility to meningococcal disease (MD) with variation in CFH, but the causal variants and underlying mechanism remained unknown. Here we attempted to define...

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Bibliographic Details
Main Authors: Kumar, V, Pouw, RB, Autio, MI, Sagmeister, MG, Phua, ZY, Borghini, L, Wright, VJ, Hoggart, C, Pan, B, Tan, AKY, Binder, A, Brouwer, MC, Pinnock, E, De Groot, R, Hazelzet, J, Emonts, M, Van Der Flier, M, Reiter, K, Nöthen, MM, Hoffmann, P, Schlapbach, LJ, Bellos, E, Anderson, S, Secka, F, Martinón-Torres, F, Salas, A, Fink, C, Carrol, ED, Pollard, AJ, Coin, LJ, Zenz, W, Wouters, D, Ang, LT, Hibberd, ML, Levin, M, Kuijpers, TW, Davila, S
Other Authors: EUCLIDS consortium
Format: Journal article
Language:English
Published: Cell Press 2022

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