A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.

Copper(II)bis(thiosemicarbazonato) complexes such as [(64)Cu]Cu-ATSM continue to be investigated for positron emission tomography (PET) imaging of tumour hypoxia. However, the currently proposed mechanisms for the mode of action of these complexes are unable to account fully for their observed biolo...

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Bibliographic Details
Main Authors: Hueting, R, Kersemans, V, Tredwell, M, Cornelissen, B, Christlieb, M, Gee, A, Passchier, J, Smart, S, Gouverneur, V, Muschel, R, Dilworth, J
Format: Journal article
Language:English
Published: Royal Society of Chemistry 2015