Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival.

Hypoxia inducible factors HIF1alpha and HIF2alpha are important proteins involved in the regulation of the transcription of a variety of genes related to erythropoiesis, glycolysis and angiogenesis. Hypoxic stimulation results in rapid increase of the HIF1alpha and 2alpha protein levels, as a conseq...

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Bibliographic Details
Main Authors: Giatromanolaki, A, Koukourakis, M, Sivridis, E, Turley, H, Talks, K, Pezzella, F, Gatter, K, Harris, A
Format: Journal article
Language:English
Published: 2001