Gamma-H2AX foci counting: Image processing and control software for high-content screening

Phosphorylation of the chromatin protein H2AX (forming γH2AX) is implicated in the repair of DNA double strand breaks (DSB's); a large number of H2AX molecules become phosphorylated at the sites of DSB's. Fluorescent staining of the cell nuclei for γH2AX, via an antibody, visualises the fo...

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Bibliographic Details
Main Authors: Barber, P, Locke, R, Pierce, G, Rothkamm, K, Vojnovic, B
Format: Journal article
Language:English
Published: 2007