A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pa...
| Главные авторы: | , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Oxford University Press
2016
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