Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme

<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...

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Bibliografski detalji
Glavni autor: Holt-Martyn, J
Daljnji autori: Schofield, C
Format: Disertacija
Izdano: 2018