Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...
المؤلف الرئيسي: | Holt-Martyn, J |
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مؤلفون آخرون: | Schofield, C |
التنسيق: | أطروحة |
منشور في: |
2018
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مواد مشابهة
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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
حسب: Holt-Martyn, J, وآخرون
منشور في: (2019) -
Structural basis of prolyl hydroxylase domain inhibition by Molidustat
حسب: Figg, WD, وآخرون
منشور في: (2021) -
Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
حسب: Holt-Martyn, JP, وآخرون
منشور في: (2019) -
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
حسب: Chowdhury, R, وآخرون
منشور في: (2013) -
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
حسب: Mecinović, J, وآخرون
منشور في: (2009)