Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme

Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme

<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Holt-Martyn, J
Awduron Eraill:	Schofield, C
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2018

Eitemau Tebyg

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
gan: Holt-Martyn, J, et al.
Cyhoeddwyd: (2019)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
gan: Figg, WD, et al.
Cyhoeddwyd: (2021)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
gan: Holt-Martyn, JP, et al.
Cyhoeddwyd: (2019)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2013)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
gan: Mecinović, J, et al.
Cyhoeddwyd: (2009)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
gan: Li, Z, et al.
Cyhoeddwyd: (2020)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
gan: Wijeyekoon, JB
Cyhoeddwyd: (2013)

Substrate selectivity of prolyl hydroxylases
gan: McDonough, M
Cyhoeddwyd: (2018)

Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
gan: Chan, MC, et al.
Cyhoeddwyd: (2015)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
gan: Mun Chiang Chan, et al.
Cyhoeddwyd: (2015-01-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
gan: Rasheduzzaman Chowdhury, et al.
Cyhoeddwyd: (2016-08-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
gan: Yeh, TL, et al.
Cyhoeddwyd: (2017)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
gan: Bush, J, et al.
Cyhoeddwyd: (2018)

Mechanistic studies on human prolyl hydroxylase domain 2
gan: Fiorini, G
Cyhoeddwyd: (2024)

Role of prolyl hydroxylase domain proteins in bone metabolism
gan: David Wolf, et al.
Cyhoeddwyd: (2022-03-01)

Prolyl hydroxylases and therapeutics.
gan: Smith, T, et al.
Cyhoeddwyd: (2010)

Pleotropic effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors: are they clinically relevant?
gan: Yu-Hsiang Chou, et al.
Cyhoeddwyd: (2023-01-01)

Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis.
gan: Muz, B, et al.
Cyhoeddwyd: (2012)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
gan: Mole, D, et al.
Cyhoeddwyd: (2003)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
gan: Schlemminger, I, et al.
Cyhoeddwyd: (2003)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
gan: Kiriakidis, S, et al.
Cyhoeddwyd: (2017)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
gan: Abboud, M, et al.
Cyhoeddwyd: (2018)

Prolyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock
gan: Xiaowu Wu, et al.
Cyhoeddwyd: (2024-02-01)

Regulation of HIF: prolyl hydroxylases.
gan: Stolze, I, et al.
Cyhoeddwyd: (2006)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
gan: Lippl, K, et al.
Cyhoeddwyd: (2015)

Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice
gan: Shunji Nishide, et al.
Cyhoeddwyd: (2020-06-01)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
gan: Mecinovic, J, et al.
Cyhoeddwyd: (2008)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
gan: Thinnes, C, et al.
Cyhoeddwyd: (2018)

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
gan: Christine Rempfer, et al.
Cyhoeddwyd: (2024-12-01)

A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats.
gan: Pierre E Signore, et al.
Cyhoeddwyd: (2021-01-01)

A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats
gan: Pierre E. Signore, et al.
Cyhoeddwyd: (2021-01-01)

Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury
gan: Zhao-Ying Ding, et al.
Cyhoeddwyd: (2022-03-01)

Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state
gan: Amit A. Joharapurkar, et al.
Cyhoeddwyd: (2022-01-01)

Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
gan: Andrey A. Poloznikov, et al.
Cyhoeddwyd: (2022-01-01)

TAF1 SPLICING VARIANTS AND PROLYL HYDROXYLASE INHIBITORS IN HUNTINGTON’S DISEASE
gan: Claudia Rodríguez-López, et al.
Cyhoeddwyd: (2023-10-01)

Bibliometric analysis of hypoxia inducible factor prolyl hydroxylase inhibitor in anemia
gan: Li Zheng, et al.
Cyhoeddwyd: (2022-09-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
gan: Andrey A. Poloznikov, et al.
Cyhoeddwyd: (2021-01-01)

Structural and mechanistic studies on prolyl hydroxylases
gan: Chowdhury, R
Cyhoeddwyd: (2008)

Inhibition of a viral prolyl hydroxylase
gan: Langley, G, et al.
Cyhoeddwyd: (2019)