Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...
Κύριος συγγραφέας: | Holt-Martyn, J |
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Άλλοι συγγραφείς: | Schofield, C |
Μορφή: | Thesis |
Έκδοση: |
2018
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
ανά: Holt-Martyn, J, κ.ά.
Έκδοση: (2019) -
Structural basis of prolyl hydroxylase domain inhibition by Molidustat
ανά: Figg, WD, κ.ά.
Έκδοση: (2021) -
Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
ανά: Holt-Martyn, JP, κ.ά.
Έκδοση: (2019) -
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2013) -
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
ανά: Mecinović, J, κ.ά.
Έκδοση: (2009)